Bleeding for 2 weeks after vaginal misoprostol for EPF is common. Heavy bleeding is usually limited to a few days after treatment. Clinically important changes in haemoglobin after misoprostol use are rare. Though uncommon, delayed episodes of prolonged or heavy bleeding requiring D&C can occur following medical management of EPF. Important Information. Misoprostol can cause birth defects, premature birth, uterine rupture, miscarriage, or incomplete miscarriage and dangerous uterine bleeding. Misoprostol helps to decrease your risk of serious ulcer complications such as bleeding. This medication protects your stomach lining by lowering the amount of acid that comes in contact with it. warning. misoprostol administration to women who are pregnant can cause birth defects, abortion, or premature birth. uterine rupture has been reported when misoprostol tablets were administered in pregnant women to induce labor or to induce abortion beyond the eighth week of pregnancy (see also precautions and labor and delivery). The objectives of this comparative study are to compare the safety, tolerability, and clinical effectiveness of oral Misoprostol, intravenous Oxytocin, and intravenous Ergometrine in the management of uterine bleeding after surgical evacuation of first trimester abortion. In a study of misoprostol stimulation of uterine contractility as measured by an intrauterine pressure catheter, buccal administration resulted in higher peak uterine tone than rectal administration (49 vs 31 mm Hg). 8 In addition, time to onset of uterine contractility was 41 minutes and 103 minutes, respectively, for buccal and rectal administration. Misoprostol, sold under the brandname Cytotec among others, is a medication used to prevent and treat stomach ulcers, start labor, cause an abortion, and treat postpartum bleeding due to poor contraction of the uterus. For the treatment of postpartum bleeding† due to uterine atony when unresponsive to massage and other uterotonic agents are not available, or when unresponsive to massage and other uterotonic agents. Rectal dosage† Adult females. 800 to 1000 mcg PR. Because of the limited data regarding safety and efficacy for this indication, misoprostol should only be used in situations where. Misoprostol is a synthetic prostaglandin E 1 analogue that is used off-label for a variety of indications in the practice of obstetrics and gynecology, including medication abortion, medical management of miscarriage, induction of labor, cervical ripening before surgical procedures, and the treatment of postpartum hemorrhage. Misoprostol is a very powerful stimulator of uterine contractions in late pregnancy and can cause fetal death and uterine rupture if used in high doses. Follow the dosage regimes carefully and do not exceed those doses.